Although effective in the lab for early development, this series of operations would be labor-intensive and wasteful at manufacturing scale. Salting-out with sodium chloride only gave a 6:1 distribution between the organic and aqueous phases, and two back extractions were still necessary to obtain >95% recovery. ![]() Consequently, its purification by aqueous workup proved challenging due to poor partitioning. While developing a synthesis for the HCV drug uprifosbuvir, (1) a number of nucleoside intermediates with high water solubilities were encountered, including chlorouridine 1 (1b) ( Figure 1).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |